Arizona Cardinals vs 49ers Match Player Stats

Key Statistics

The Arizona Cardinals vs 49ers rivalry produced two regular-season meetings in 2025, with San Francisco winning both games. Arizona lost 16-15 at Levi’s Stadium on September 21, 2025, then lost 41-22 at State Farm Stadium on November 16, 2025. San Francisco therefore swept the 2025 series by an aggregate 57-37.

2025 Match Results

Date	Venue	Winner	Score	Margin
Sept. 21, 2025	Levi’s Stadium	San Francisco 49ers	16-15	SF +1
Nov. 16, 2025	State Farm Stadium	San Francisco 49ers	41-22	SF +19
2025 series	—	49ers	57-37	SF +20

September 21, 2025 — Player Statistics

Category	Arizona Cardinals	San Francisco 49ers
Passing	Kyler Murray: 22/35, 159 yds, 1 TD, 0 INT	Mac Jones: 27/41, 284 yds, 1 TD, 1 INT
Passer rating	82.9	83.8
Leading rusher	Trey Benson: 10 carries, 42 yds	Christian McCaffrey: 17 carries, 52 yds
Leading receiver	Marvin Harrison Jr.: 3 rec, 44 yds	Ricky Pearsall: 8 rec, 117 yds
Top target	Trey McBride: 8 targets	Christian McCaffrey: 15 targets
Receiving TD	Trey McBride: 1	Kyle Juszczyk: 1
Interceptions	Dadrion Taylor-Demerson: 1	—
Total offense	260 yds	355 yds
Rushing	106 yds	73 yds
Net passing	154 yds	282 yds
First downs	16	19
Turnovers	0	1
Time of possession	34:39	25:21

The official NFL gamebook records 355 total yards for San Francisco against 260 for Arizona. The Cardinals controlled possession for more than 34 minutes and rushed for 106 yards, but the 49ers produced 282 net passing yards and made three field goals. Arizona’s safety gave the Cardinals a 15-13 lead late, but San Francisco won on a 35-yard Eddy Piñeiro field goal.

September 21, 2025 — Passing

Player	Team	Cmp/Att	Pass Yds	TD	INT	Rating
Kyler Murray	Cardinals	22/35	159	1	0	82.9
Mac Jones	49ers	27/41	284	1	1	83.8

September 21, 2025 — Rushing

Player	Team	Carries	Yards	Avg.	Long	TD
Trey Benson	Cardinals	10	42	4.2	29	0
Kyler Murray	Cardinals	6	37	6.2	9	0
James Conner	Cardinals	9	22	2.4	9	0
Christian McCaffrey	49ers	17	52	3.1	15	0
Brian Robinson	49ers	2	22	11.0	19	0
Jordan Mason	49ers	1	-1	-1.0	-1	0

September 21, 2025 — Receiving

Player	Team	Targets	Rec.	Yards	Avg.	Long	TD
Trey McBride	Cardinals	8	5	43	8.6	17	1
Marvin Harrison Jr.	Cardinals	6	3	44	14.7	32	0
James Conner	Cardinals	4	3	15	5.0	10	0
Trey Benson	Cardinals	4	3	9	3.0	5	0
Ricky Pearsall	49ers	11	8	117	14.6	34	0
Christian McCaffrey	49ers	15	10	88	8.8	20	0
Kendrick Bourne	49ers	6	4	38	9.5	11	0
Jake Tonges	49ers	3	2	21	10.5	11	0
Kyle Juszczyk	49ers	1	1	1	1.0	1	1

The official individual statistics show Pearsall as San Francisco’s leading receiver and McCaffrey with 10 receptions, 88 receiving yards and 15 targets.

November 16, 2025 — Player Statistics

Category	San Francisco 49ers	Arizona Cardinals
Passing	Brock Purdy: 19/26, 200 yds, 3 TD, 0 INT	Jacoby Brissett: 47/57, 452 yds, 2 TD, 2 INT
Passer rating	133.5	96.8
Leading rusher	Christian McCaffrey: 13 carries, 81 yds, 2 TD	Zonovan Knight: 5 carries, 24 yds, 1 TD
Leading receiver	George Kittle: 6 rec, 67 yds, 2 TD	Michael Wilson: 15 rec, 185 yds
Receiving TD leader	George Kittle: 2	Trey McBride and Greg Dortch: 1 each
Interceptions	Deommodore Lenoir, Malik Mustapha	—
Total offense	281 yds	488 yds
Rushing	95 yds	36 yds
Net passing	186 yds	452 yds
First downs	24	24
Turnovers	0	3
Time of possession	25:45	34:15

Arizona actually outgained San Francisco 488-281 and produced 452 net passing yards, but the 49ers scored five touchdowns, committed no turnovers, went 4-for-5 in the red zone and benefited from Arizona’s three turnovers and 17 penalties for 130 yards.

November 16, 2025 — Passing

Player	Team	Cmp/Att	Pass Yds	TD	INT	Rating
Brock Purdy	49ers	19/26	200	3	0	133.5
Jacoby Brissett	Cardinals	47/57	452	2	2	96.8

November 16, 2025 — Rushing

Player	Team	Carries	Yards	Avg.	Long	TD
Christian McCaffrey	49ers	13	81	6.2	20	2
Brian Robinson	49ers	8	24	3.0	7	0
Emanuel Wilson	49ers	5	8	1.6	5	0
Mac Jones	49ers	2	6	3.0	3	0
Zonovan Knight	Cardinals	5	24	4.8	7	1
Emari Demercado	Cardinals	5	8	1.6	5	0
Michael Carter	Cardinals	2	6	3.0	3	0
Jacoby Brissett	Cardinals	2	-2	-1.0	2	0

November 16, 2025 — Receiving

Player	Team	Targets	Rec.	Yards	Avg.	Long	TD
George Kittle	49ers	6	6	67	11.2	30	2
Christian McCaffrey	49ers	6	5	40	8.0	15	1
Jauan Jennings	49ers	6	4	54	13.5	25	0
Kyle Juszczyk	49ers	2	2	26	13.0	21	0
Demarcus Robinson	49ers	2	1	13	13.0	13	0
Ricky Pearsall	49ers	3	1	0	0.0	0	0
Michael Wilson	Cardinals	18	15	185	12.3	34	0
Trey McBride	Cardinals	11	10	115	11.5	28	1
Greg Dortch	Cardinals	6	6	66	11.0	17	1
Michael Carter	Cardinals	7	5	22	4.4	7	0
Zonovan Knight	Cardinals	4	4	21	5.3	12	0
Xavier Weaver	Cardinals	3	2	15	7.5	9	0

The official NFL gamebook confirms Wilson’s 15-catch, 185-yard performance, McBride’s 10 catches for 115 yards and Kittle’s two touchdown receptions.

Career Overview

The Arizona Cardinals and San Francisco 49ers are NFC

with a rivalry that spans multiple franchise eras. The Cardinals franchise has existed since 1920, while the 49ers entered the NFL in 1946.

Through the 2025 season, San Francisco leads the all-time series 38-31-0 in 69 meetings. The 49ers have scored 1,628 points in those games compared with 1,434 for the Cardinals. Neither team has won a playoff game against the other because they have never met in the postseason.

The rivalry is part of the NFC West, making the games regular-season divisional contests with significant implications for division standings and playoff positioning.

The 2025 matchup featured several of the league’s most productive offensive players. San Francisco’s attack was led by Christian McCaffrey, Brock Purdy and George Kittle. Arizona’s principal offensive contributors included Trey McBride, Michael Wilson, Jacoby Brissett and, in the first meeting, Kyler Murray.

Career Statistics

Because this keyword targets a team-vs-team matchup, career statistics are presented for the principal players who defined the recent Cardinals-49ers meetings, along with each franchise’s historical leaders.

Principal Player Career Statistics

Player	Team	Pos.	Games	Career Passing Yds	Career Rush Yds	Career Rec.	Career Rec. Yds	Career TDs
Christian McCaffrey	49ers	RB	112	—	7,589	543*	5,198*	85*
George Kittle	49ers	TE	124	—	-3	595	8,008	52
Trey McBride	Cardinals	TE	66	—	2	347	3,475	17
Kyler Murray	Cardinals	QB	87	20,460	3,193	0	7	153

*McCaffrey’s receiving totals are included for context; his official career summary records 112 games, 1,658 rushing attempts, 7,589 rushing yards and 62 rushing touchdowns through 2025.

Kittle’s career through the 2025 regular season stands at 124 games, 595 receptions, 8,008 yards and 52 receiving touchdowns.

McBride entered 2026 with 347 receptions, 3,475 yards and 17 receiving touchdowns in 66 games.

Murray’s NFL career totals through 2025 include 20,460 passing yards, 121 passing touchdowns, 60 interceptions, 3,193 rushing yards and 32 rushing touchdowns.

Franchise Career Leaders

Category	San Francisco 49ers	Arizona Cardinals
Passing yards	Joe Montana — 35,124	Jim Hart — 34,639
Rushing yards	Frank Gore — 11,073	Ottis Anderson — 7,999
Receiving yards	Jerry Rice — 19,247	Larry Fitzgerald — 17,492
Receiving TDs	Jerry Rice — 176	Larry Fitzgerald — 121
Career AV	Jerry Rice — 216	Larry Fitzgerald — 138
Scoring	Jerry Rice — 1,130 points	Jim Bakken — 1,380 points

The Cardinals franchise records include the team’s Chicago, St. Louis, Phoenix and Arizona eras. San Francisco’s records cover the 49ers’ NFL history beginning in 1946.

Season-by-Season Stats

Arizona Cardinals — 2021-2025

Season	Record	Division Finish	Points For	Points Against	Playoffs
2021	11-6	2nd	449	366	Lost Wild Card
2022	4-13	4th	340	449	Did not qualify
2023	4-13	4th	330	455	Did not qualify
2024	8-9	3rd	400	379	Did not qualify
2025	3-14	4th	355	488	Did not qualify

Arizona improved from 4-13 in 2023 to 8-9 in 2024 before falling to 3-14 in 2025.

San Francisco 49ers — 2021-2025

Season	Record	Division Finish	Points For	Points Against	Playoffs
2021	10-7	3rd	427	365	Lost NFC Championship
2022	13-4	1st	450	277	Lost NFC Championship
2023	12-5	1st	491	298	Lost Super Bowl
2024	6-11	4th	389	436	Did not qualify
2025	12-5	2nd	437	371	Lost Divisional Round

San Francisco’s 2025 season restored the team to a 12-win level after its 6-11 campaign in 2024. The 49ers reached the divisional round after beating Philadelphia 23-19 in the Wild Card round.

Key Player Seasonal Production

Christian McCaffrey

Season	Team	Games	Rush Yds	Rush TD	Receptions	Rec. Yds	Rec. TD
2022	SF	14*	746*	6*	52*	464*	1*
2023	SF	16	1,459	14	67	564	7
2024	SF	4	202	0	7	68	0
2025	SF	17	1,202	10	102	924	7

*The 2022 figures reflect McCaffrey’s combined season after his midseason move from Carolina to San Francisco. His San Francisco portion alone was 746 rushing yards and 464 receiving yards. His 2025 season produced 2,126 yards from scrimmage.

George Kittle

Season	Team	Games	Receptions	Receiving Yards	TD
2021	SF	14	71	910	6
2022	SF	15	60	765	11
2023	SF	16	65	1,020	6
2024	SF	15	78	1,106	8
2025	SF	11	57	628	7

Kittle reached 1,000 receiving yards in both 2023 and 2024 and finished his 2025 regular season with 57 receptions, 628 yards and seven touchdowns.

Trey McBride

Season	Team	Games	Receptions	Receiving Yards	TD
2022	ARI	16	29	265	1
2023	ARI	17	81	825	3
2024	ARI	16	111	1,146	2
2025	ARI	17	126	1,239	11

McBride’s receiving output increased sharply from 29 receptions as a rookie to 126 receptions in 2025.

Kyler Murray

Season	Games	Completions	Attempts	Passing Yards	TD	INT	Rating	Rush Yards	Rush TD
2019	16	349	542	3,722	20	12	87.4	544	4
2020	16	375	558	3,971	26	12	94.3	819	11
2021	14	333	481	3,787	24	10	100.6	423	5
2022	11	259	390	2,368	14	7	87.2	418	3
2023	8	176	268	1,799	10	5	89.4	244	3
2024	17	372	541	3,851	21	11	93.5	572	5
2025	5	110	161	962	6	3	88.6	173	1

Murray finished his Cardinals career with 20,460 passing yards, 121 passing touchdowns and 3,193 rushing yards.

Records

Arizona Cardinals vs 49ers Series Records

Record	Figure
All-time meetings	69
49ers wins	38
Cardinals wins	31
Ties	0
49ers winning percentage	.551
Cardinals winning percentage	.449
Playoff meetings	0
49ers series points	1,628
Cardinals series points	1,434

San Francisco’s 38-31 advantage gives the 49ers a .551 winning percentage in the rivalry.

2025 Match Records and Milestones

• San Francisco swept Arizona 2-0 in 2025.
• The 49ers won the first meeting by one point, 16-15.
• The 49ers won the second meeting by 19 points, 41-22.
• Arizona produced 488 total yards in the second meeting but still lost by 19.
• Jacoby Brissett threw for 452 yards in that game.
• Michael Wilson recorded 185 receiving yards, the highest single-game receiving total in the 2025 series.
• George Kittle scored two receiving touchdowns in the November game.
• Christian McCaffrey scored three total touchdowns in the November game.
• San Francisco committed zero turnovers in the November victory.
• Arizona committed three turnovers in the November game.
• Arizona was penalized 17 times for 130 yards in November.

Defensive Milestones in the 2025 Series

In the November meeting, Deommodore Lenoir and Malik Mustapha each intercepted Brissett. Lenoir finished with seven combined tackles and an interception, while Mustapha added four combined tackles and an interception. Charlie Robinson led San Francisco with 11 combined tackles.

In September, Arizona’s Dadrion Taylor-Demerson recorded the game’s only interception, while San Francisco’s Nick Bosa was credited with a forced fumble.

Awards and Honors

Christian McCaffrey

McCaffrey’s 2025 season produced several major honors. He was named Associated Press Comeback Player of the Year, selected as a first-team AP All-Pro, and named a 2026 Pro Bowl running back. He also won the FedEx Ground Player of the Year and Salute to Service Award.

His 2025 statistical profile included 1,202 rushing yards, 924 receiving yards and 2,126 scrimmage yards. He also set a 49ers franchise record with 413 touches.

George Kittle

Kittle was selected to the 2026 Pro Bowl after his 2025 season with 57 receptions, 628 yards and seven touchdowns. He has also earned multiple Pro Bowl and All-Pro selections during his San Francisco career.

Trey McBride

McBride was named a first-team AP All-Pro for 2025 and was selected as the NFC’s starting tight end for the 2026 Pro Bowl Games. His 2025 season produced 126 receptions, 1,239 receiving yards and 11 touchdowns.

Kyler Murray

Murray won 2019 AP Offensive Rookie of the Year and has been selected to two Pro Bowls. His 2020 season remains his statistical peak as a passer, with 3,971 yards and 26 passing touchdowns, while he also rushed for 819 yards and 11 touchdowns.

Historical Cardinals and 49ers Honors

The rivalry has included players who rank among the most decorated figures in franchise history. Jerry Rice is San Francisco’s all-time leader in receiving yards, receiving touchdowns and Approximate Value, while Larry Fitzgerald holds the corresponding major receiving records for the Cardinals.

Performance Trends

San Francisco’s 2025 Efficiency Advantage

The two 2025 games produced very different statistical profiles.

In September, San Francisco won the yardage battle 355-260. The 49ers generated 282 net passing yards while Arizona had 154. Arizona had the better rushing total, 106-73, and held a 34:39-25:21 time-of-possession advantage, but San Francisco made three field goals and scored the winning points late.

In November, the yardage picture reversed dramatically. Arizona generated 488 yards to San Francisco’s 281, but the Cardinals turned that production into only 22 points. The 49ers scored 41 despite running only 52 offensive plays.

Turnovers and Red-Zone Efficiency

Metric, 2025	Sept. 21	Nov. 16
49ers turnovers	1	0
Cardinals turnovers	0	3
49ers red-zone efficiency	25%	80%
Cardinals red-zone efficiency	33%	60%
49ers touchdowns	1	5
Cardinals touchdowns	1	3

The November game is the clearest example of efficiency overriding raw yardage. Arizona had 207 more total yards, but San Francisco had a +3 turnover margin, scored two more touchdowns and converted 80% of its red-zone opportunities.

McCaffrey’s Role

McCaffrey was central to San Francisco’s offensive production in the second meeting. He combined 81 rushing yards, two rushing touchdowns, 40 receiving yards and a receiving touchdown. His three touchdowns accounted for 18 of the 49ers’ 41 points directly.

His full 2025 season was even more productive: 2,126 scrimmage yards and 17 total touchdowns across 17 games.

Arizona’s Passing-Heavy Profile

Arizona’s November offense was almost entirely driven through the air. Brissett completed 47 of 57 attempts for 452 yards. The Cardinals had just 36 rushing yards on 14 attempts, compared with 452 net passing yards.

The Cardinals’ full 2025 team statistics reinforce that imbalance: Arizona ranked near the top of the league in passing volume while finishing with only 1,583 rushing yards.

Historical Context

San Francisco has the stronger franchise résumé. The 49ers have won five Super Bowls in eight appearances, while the Cardinals have appeared in one Super Bowl and have not won one.

The historical statistical leaders also show a substantial difference in elite receiving production. Jerry Rice finished his 49ers career with 19,247 receiving yards and 176 receiving touchdowns. Larry Fitzgerald finished his Cardinals career with 17,492 receiving yards and 121 touchdowns.

At quarterback, Joe Montana’s 35,124 passing yards remain the 49ers’ franchise record. Jim Hart holds the Cardinals’ record with 34,639 yards.

The modern rivalry is more balanced than those franchise résumés might suggest. San Francisco leads only 38-31, meaning Arizona has won 31 of the 69 meetings. The lack of playoff meetings is also unusual for two long-term NFC West opponents.

2025 vs. NFL Offensive Environment

The NFL averaged 116.9 rushing yards and 209.7 passing yards per team per game in 2025. The Cardinals’ 2025 offense was built much more heavily around passing, while San Francisco’s offense had an unusually versatile centerpiece in McCaffrey.

San Francisco’s 2025 team finished with 437 points, 5,974 total yards and a 12-5 record. Arizona finished with 355 points, 5,538 total yards and a 3-14 record.

Head-to-Head Statistics

All-Time Head-to-Head Record

Statistic	Arizona Cardinals	San Francisco 49ers
Games	69	69
Wins	31	38
Losses	38	31
Ties	0	0
Winning percentage	.449	.551
Playoff meetings	0	0
Series points	1,434	1,628

2025 Head-to-Head Comparison

Statistic	Cardinals	49ers	Advantage
Games won	0	2	49ers
Aggregate points	37	57	49ers
Aggregate point margin	-20	+20	49ers
Sept. total yards	260	355	49ers
Nov. total yards	488	281	Cardinals
Sept. rushing yards	106	73	Cardinals
Nov. rushing yards	36	95	49ers
Sept. net passing yards	154	282	49ers
Nov. net passing yards	452	186	Cardinals
2025 turnovers in two meetings	3	1	49ers
2025 wins	0	2	49ers

The split in yardage is notable: Arizona had more total yards in the second game but still lost 41-22. San Francisco’s two wins were therefore produced by different statistical formulas.

2025 Player Head-to-Head

Player	Team	Sept. 21	Nov. 16
Christian McCaffrey	49ers	52 rush, 88 rec	81 rush, 40 rec, 3 TD
George Kittle	49ers	Did not record a listed reception	6 rec, 67 yds, 2 TD
Ricky Pearsall	49ers	8 rec, 117 yds	1 rec, 0 yds
Trey McBride	Cardinals	5 rec, 43 yds, 1 TD	10 rec, 115 yds, 1 TD
Michael Wilson	Cardinals	1 rec, 5 yds	15 rec, 185 yds
Kyler Murray	Cardinals	22/35, 159 yds, 1 TD	Did not play
Brock Purdy	49ers	Did not play	19/26, 200 yds, 3 TD
Jacoby Brissett	Cardinals	Did not play	47/57, 452 yds, 2 TD, 2 INT
Mac Jones	49ers	27/41, 284 yds, 1 TD, 1 INT	Did not play

Recent Form

The 2025 NFL season is the most recent completed season available for this matchup.

San Francisco 49ers — 2025

Category	Result
Regular-season record	12-5
NFC West finish	2nd
Points scored	437
Points allowed	371
Wild Card	Won 23-19 vs. Philadelphia
Divisional Round	Lost 6-41 vs. Seattle
Final playoff round	Divisional

San Francisco’s 12-5 regular-season record placed the 49ers second in the NFC West. The team defeated Philadelphia in the Wild Card round before losing to Seattle in the divisional round.

Arizona Cardinals — 2025

Category	Result
Regular-season record	3-14
NFC West finish	4th
Points scored	355
Points allowed	488
Playoffs	Did not qualify
Total yards	5,538
Passing yards	3,955
Rushing yards	1,583

Arizona finished 2025 with a 3-14 record and ranked 29th in points allowed at 28.7 per game. The offense produced 3,955 passing yards and 1,583 rushing yards.

2025 Key Player Form

Player	2025 Regular Season
Christian McCaffrey	1,202 rush yds, 10 rush TD; 102 rec, 924 rec yds, 7 rec TD
George Kittle	57 rec, 628 yds, 7 TD
Brock Purdy	2,167 pass yds, 20 TD, 10 INT
Trey McBride	126 rec, 1,239 yds, 11 TD
Michael Wilson	78 rec, 1,006 yds, 7 TD
Jacoby Brissett	3,366 pass yds, 23 TD, 8 INT

Statistical Highlights

• 38-31: San Francisco’s all-time lead over Arizona in 69 meetings.
• 2-0: San Francisco’s record against Arizona in the 2025 regular season.
• 57-37: Aggregate 2025 score in favor of San Francisco.
• 16-15: San Francisco’s September 2025 victory.
• 41-22: San Francisco’s November 2025 victory.
• 488: Arizona’s total yards in the November game.
• 281: San Francisco’s total yards in that same game.
• 452: Jacoby Brissett’s passing yards in the November meeting.
• 200: Brock Purdy’s passing yards in the November meeting.
• 133.5: Purdy’s passer rating in that game.
• 185: Michael Wilson’s receiving yards against San Francisco in November.
• 115: Trey McBride’s receiving yards in November.
• 67: George Kittle’s receiving yards in November.
• 3: McCaffrey’s total touchdowns in the November meeting.
• 3: Arizona turnovers in the November meeting.
• 0: San Francisco turnovers in that game.
• 17: Arizona penalties in November.
• 130: Arizona penalty yards in November.
• 80%: San Francisco red-zone efficiency in November.
• 1,239: McBride’s 2025 receiving yards.
• 1,202: McCaffrey’s 2025 rushing yards.
• 2,126: McCaffrey’s 2025 scrimmage yards.
• 20,460: Kyler Murray’s career passing yards through 2025.
• 19,247: Jerry Rice’s career 49ers receiving yards.
• 17,492: Larry Fitzgerald’s career Cardinals receiving yards.

Frequently Asked Questions

Who won the Arizona Cardinals vs 49ers games in 2025?

The San Francisco 49ers won both meetings. San Francisco defeated Arizona 16-15 on September 21 and 41-22 on November 16, 2025.

What was the 49ers vs Cardinals record in 2025?

The 49ers finished 2-0 against the Cardinals in 2025.

What is the all-time Cardinals vs 49ers record?

San Francisco leads the all-time series 38-31, with no ties across 69 meetings.

Who was the best player in the 49ers vs Cardinals matchup?

Christian McCaffrey produced the most significant individual scoring performance of the 2025 series. On November 16, he rushed for 81 yards and two touchdowns and added a receiving touchdown.

How many yards did Michael Wilson have against the 49ers?

Michael Wilson caught 15 passes for 185 yards against San Francisco on November 16, 2025.

How many receiving yards did Trey McBride have against San Francisco?

McBride had 43 receiving yards and one touchdown in the September meeting, followed by 115 yards and one touchdown in November. His combined 2025 output against San Francisco was therefore 15 receptions, 158 yards and two touchdowns.

How many passing yards did Jacoby Brissett have against the 49ers?

Brissett completed 47 of 57 passes for 452 yards, two touchdowns and two interceptions in the November 16, 2025 game.

How many passing yards did Brock Purdy have against Arizona?

Purdy completed 19 of 26 passes for 200 yards and three touchdowns, without an interception, in the November 16 victory.

Did Kyler Murray play against the 49ers in 2025?

Yes. Murray started the September 21 meeting and completed 22 of 35 passes for 159 yards and one touchdown, while rushing for 37 yards.

Who had the most receiving yards in the 2025 Cardinals vs 49ers games?

Michael Wilson had the highest single-game total with 185 receiving yards on November 16. Ricky Pearsall was San Francisco’s leading receiver in the September game with 117 yards.

Which team had more total yards in the November 2025 game?

Arizona had 488 total yards, compared with San Francisco’s 281. Despite that 207-yard advantage, Arizona lost 41-22 because San Francisco had the superior turnover and red-zone efficiency.

Who scored the most touchdowns in the 49ers vs Cardinals 2025 series?

Christian McCaffrey scored three touchdowns in the November game alone. George Kittle scored two receiving touchdowns in that game.

What was Christian McCaffrey’s 2025 season?

McCaffrey played all 17 regular-season games, rushing for 1,202 yards and 10 touchdowns and catching 102 passes for 924 yards and seven touchdowns. His 2,126 scrimmage yards ranked second in the NFL, and he earned AP Comeback Player of the Year and first-team All-Pro honors.

What was Trey McBride’s 2025 season?

McBride caught 126 passes for 1,239 yards and 11 touchdowns in 17 games. He was named a first-team AP All-Pro and selected as the NFC’s starting tight end for the 2026 Pro Bowl Games.

Have the Cardinals and 49ers ever met in the playoffs?

No. The franchises have played 69 times through 2025 but have never met in a playoff game.

Sources and References

• NFL official gamebook — Cardinals at 49ers, September 21, 2025
• NFL official gamebook — 49ers at Cardinals, November 16, 2025
• Pro Football Reference — 49ers vs. Cardinals head-to-head records
• Pro Football Reference — Arizona Cardinals franchise records and leaders
• Pro Football Reference — San Francisco 49ers franchise records and leaders
• Pro Football Reference — 2025 Arizona Cardinals statistics and roster
• Pro Football Reference — 2025 San Francisco 49ers statistics and roster
• NFL — 2025 AP All-Pro Team
• NFL — 2025 NFL Honors award winners
• NFL — Christian McCaffrey named 2025 AP Comeback Player of the Year
• NFL — 2026 Pro Bowl Games NFC roster

All matchup statistics in this article are based primarily on official NFL gamebooks, with franchise history, career totals and season statistics cross-checked against Pro Football Reference and NFL statistical records. Where a statistic was not directly verifiable from those sources, it has not been presented as fact.