49ers vs arizona cardinals match player stats
The most recent completed 49ers vs Arizona Cardinals matchups were both played in the 2025 NFL regular season, with San Francisco winning both games
Key Statistics
The most recent completed 49ers vs Arizona Cardinals matchups were both played in the 2025 NFL regular season, with San Francisco winning both games: 16-15 on September 21, 2025, at Levi’s Stadium and 41-22 on November 16, 2025, at State Farm Stadium. The two victories gave San Francisco a 2-0 season sweep and extended its all-time series lead to 38-31.
49ers vs Cardinals 2025 Match Summary
| Statistic | Sept. 21, 2025 | Nov. 16, 2025 | 2025 Series |
|---|---|---|---|
| Winner | 49ers | 49ers | 49ers, 2-0 |
| Final score | SF 16, ARI 15 | SF 41, ARI 22 | SF 57, ARI 37 |
| 49ers total yards | 355 | 281 | 636 |
| Cardinals total yards | 260 | 488 | 748 |
| 49ers passing yards | 284 gross / 282 net | 200 gross / 186 net | 484 gross |
| Cardinals passing yards | 159 gross / 154 net | 452 | 611 gross |
| 49ers rushing yards | 73 | 95 | 168 |
| Cardinals rushing yards | 106 | 36 | 142 |
| 49ers turnovers | 1 | 0 | 1 |
| Cardinals turnovers | 1 | 3 | 4 |
| 49ers touchdowns | 1 | 5 | 6 |
| Cardinals touchdowns | 1 | 3 | 4 |
| 49ers first downs | 19 | 24 | 43 |
| Cardinals first downs | 16 | 24 | 40 |
| 49ers red-zone efficiency | 25% | 80% | — |
| Cardinals red-zone efficiency | 33% | 60% | — |
The first game was decided by a field goal at the final whistle. The second produced a much larger margin despite Arizona gaining 488 yards to San Francisco’s 281. Turnovers, penalties and red-zone efficiency were major differences in the November result.
September 21, 2025 — Player Statistics
| Player | Team | Passing | Rushing | Receiving | TDs |
| Mac Jones | 49ers | 27/41, 284 yds, 1 TD, 1 INT | 1/-1 | — | 1 pass |
| Kyler Murray | Cardinals | 22/35, 159 yds, 1 TD, 0 INT | 6-37 | — | 1 pass |
| Christian McCaffrey | 49ers | — | 17-52, 3.1 avg | 10-88 | 0 |
| Trey Benson | Cardinals | — | 10-42, 4.2 avg | 3-9 | 0 |
| Ricky Pearsall | 49ers | — | — | 8-117, 34 long | 0 |
| Trey McBride | Cardinals | — | — | 5-43 | 1 |
| Kyle Juszczyk | 49ers | — | — | 1-1 | 1 |
| Marvin Harrison Jr. | Cardinals | — | — | 3-44, 32 long | 0 |
Mac Jones finished with a passer rating of 83.8, while Murray posted an 82.9 rating. McCaffrey led San Francisco in rushing and receiving, while Pearsall’s 117 receiving yards were the game’s highest receiving total.
November 16, 2025 — Player Statistics
| Player | Team | Passing | Rushing | Receiving | TDs |
| Brock Purdy | 49ers | 19/26, 200 yds, 3 TD, 0 INT | 1/-7 | — | 3 pass |
| Jacoby Brissett | Cardinals | 47/57, 452 yds, 2 TD, 2 INT | 2/-2 | — | 2 pass |
| Christian McCaffrey | 49ers | — | 13-81, 6.2 avg | 5-40 | 3 total |
| George Kittle | 49ers | — | — | 6-67 | 2 |
| Michael Wilson | Cardinals | — | — | 15-185 | 0 |
| Trey McBride | Cardinals | — | — | 10-115 | 1 |
| Greg Dortch | Cardinals | — | — | 6-66 | 1 |
| Jauan Jennings | 49ers | — | — | 4-54 | 0 |
| Kyle Juszczyk | 49ers | — | — | 2-26 | 0 |
| Zonovan Knight | Cardinals | — | 5-24 | 4-21 | 1 rushing |
Purdy produced a 133.5 passer rating with three touchdown passes and no interceptions. Brissett threw for 452 yards, but his two interceptions contributed to Arizona’s three-turnover total.
Career Overview
The San Francisco 49ers and Arizona Cardinals are NFC West franchises with a rivalry dating back decades. Through the 2025 season, they had played 69 games, with San Francisco holding a 38-31-0 advantage. The franchises have never met in the playoffs.
The matchup has historically featured periods of dominance by both teams. San Francisco won four consecutive meetings from November 2022 through December 2023, Arizona then won both 2024 meetings, and San Francisco reclaimed the matchup by sweeping both games in 2025.
Recent Rivalry Results
| Date | Venue | Result |
| Oct. 10, 2021 | Arizona | Cardinals 17-10 |
| Nov. 7, 2021 | San Francisco | Cardinals 31-17 |
| Nov. 21, 2022 | Arizona | 49ers 38-10 |
| Jan. 8, 2023 | San Francisco | 49ers 38-13 |
| Oct. 1, 2023 | San Francisco | 49ers 35-16 |
| Dec. 17, 2023 | Arizona | 49ers 45-29 |
| Oct. 6, 2024 | San Francisco | Cardinals 24-23 |
| Jan. 5, 2025 | Arizona | Cardinals 47-24 |
| Sept. 21, 2025 | San Francisco | 49ers 16-15 |
| Nov. 16, 2025 | Arizona | 49ers 41-22 |
Arizona went 2-6 against San Francisco from 2022 through the 2025 season, including the two 2024 wins and six losses in the other meetings.
Career Statistics
Because 49ers vs Arizona Cardinals match player stats is a matchup rather than an individual-player search, career statistics are presented for the principal players and historical franchise leaders most relevant to the rivalry.
Christian McCaffrey — Career Regular-Season Statistics
| Category | Career total through 2025 |
| Games | 112 |
| Rushing attempts | 1,658 |
| Rushing yards | 7,589 |
| Rushing average | 4.6 |
| Rushing TDs | 62 |
| Receptions | 626 |
| Receiving yards | 5,390 |
| Receiving TDs | 36 |
| Total scrimmage yards | 12,979 |
| Total offensive TDs | 98 |
McCaffrey’s 2025 season added 1,202 rushing yards and 924 receiving yards, giving him 2,126 yards from scrimmage and 17 touchdowns for the season.
George Kittle — Career Regular-Season Statistics
| Category | Career total through 2025 |
| Games | 124 |
| Receptions | 595 |
| Receiving yards | 8,008 |
| Receiving average | 13.5 |
| Receiving TDs | 52 |
| Long reception | 85 yards |
| Rushing attempts | 13 |
| Rushing yards | 68 |
Kittle’s 8,008 career receiving yards rank among the most productive tight-end totals in NFL history. His 2018 season included 1,377 receiving yards, while his 2024 season produced 1,106 yards.
Trey McBride — Career Regular-Season Statistics
| Category | Career total through 2025 |
| Games | 66 |
| Receptions | 347 |
| Targets | 461 |
| Receiving yards | 3,475 |
| Receiving average | 10.0 |
| Receiving TDs | 17 |
| Long reception | 38 yards |
| First downs | 180 |
McBride has increased his production every season since entering the NFL. His receiving totals rose from 29 receptions in 2022 to 81 in 2023, 111 in 2024 and 126 in 2025.
Kyler Murray — Arizona Career Statistics
| Category | Career total through 2025 Arizona tenure |
| Games | 87 |
| Pass attempts | 2,941 |
| Completions | 1,974 |
| Completion percentage | 67.1% |
| Passing yards | 20,460 |
| Passing TDs | 121 |
| Interceptions | 60 |
| Passer rating | 92.2 |
| Rushing attempts | 532 |
| Rushing yards | 3,193 |
| Rushing TDs | 32 |
Murray’s Arizona career included 3,971 passing yards and 26 touchdown passes in 2020, and 3,851 passing yards with 21 touchdowns in 2024.
Franchise Career Leaders
| Category | 49ers leader | Cardinals leader |
| Passing yards | Joe Montana — 35,124 | Jim Hart — 34,639 |
| Rushing yards | Frank Gore — 11,073 | Ottis Anderson — 7,999 |
| Receiving yards | Jerry Rice — 19,247 | Larry Fitzgerald — 17,492 |
| Receiving TDs | Jerry Rice — 176 | Larry Fitzgerald — 121 |
| Scoring | Jerry Rice — 1,130 points | Jim Bakken — 1,380 points |
| Approx. career AV leader | Jerry Rice — 216 | Larry Fitzgerald — 138 |
San Francisco’s franchise leaders reflect the team’s long-term offensive history, while Fitzgerald’s 17,492 receiving yards remain the Cardinals’ defining receiving benchmark.
Season-by-Season Stats
49ers vs Cardinals Series, 2021-2025
| Season | Games | 49ers wins | Cardinals wins | Series score |
| 2021 | 2 | 0 | 2 | ARI 48-27 |
| 2022 | 1 | 1 | 0 | SF 38-10 |
| 2023 | 2 | 2 | 0 | SF 80-45 |
| 2024 | 1 | 0 | 1 | ARI 24-23 |
| 2025 | 2 | 2 | 0 | SF 57-37 |
The 2023 season was San Francisco’s most productive recent series, with the 49ers scoring 80 points in two games. Arizona reversed the trend in 2024 with a 24-23 win at Levi’s Stadium, followed by San Francisco’s two-game sweep in 2025.
San Francisco 49ers Team Stats, 2023-2025
| Season | Record | Points For | Points Against | Total Offensive Yards |
| 2023 | 12-5 | 491 | 298 | 6,793 |
| 2024 | 6-11 | 389 | 436 | 5,? |
| 2025 | 12-5 | 437 | 371 | 5,974 |
The verified 2025 figures show San Francisco returning to a 12-5 record after a 6-11 campaign in 2024. The 2025 49ers averaged 25.7 points per game and allowed 21.8.
Arizona Cardinals Team Stats, 2023-2025
| Season | Record | Points For | Points Against |
| 2023 | 4-13 | 330 | 455 |
| 2024 | 8-9 | 400 | 379 |
| 2025 | 3-14 | 355 | 488 |
Arizona’s 2025 record dropped to 3-14 after an 8-9 season in 2024. The Cardinals scored 20.9 points per game and allowed 28.7 in 2025.
2025 Key Player Season Stats
| Player | Team | Games | Rushing | Receiving | Passing |
| Christian McCaffrey | SF | 17 | 311-1,202-10 TD | 102-924-7 TD | — |
| George Kittle | SF | 11 | 1–3 | 57-628-7 TD | — |
| Jauan Jennings | SF | 15 | — | 55-643-9 TD | — |
| Trey McBride | ARI | 17 | — | 126-1,239-11 TD | — |
| Michael Wilson | ARI | 17 | — | 78-1,006-7 TD | — |
| Michael Carter | ARI | 13 | 92-333-1 TD | 33-267 | — |
| Kyler Murray | ARI | 5 | 29-173-1 TD | — | 110/161, 962 yds, 6 TD, 3 INT |
McCaffrey led San Francisco with 2,126 scrimmage yards. McBride led Arizona with 1,239 receiving yards and 11 receiving touchdowns.
Records
49ers vs Cardinals Head-to-Head Records
| Record | Figure |
| All-time meetings | 69 |
| 49ers wins | 38 |
| Cardinals wins | 31 |
| Ties | 0 |
| 49ers winning percentage | .551 |
| 49ers points in series | 1,628 |
| Cardinals points in series | 1,434 |
| Playoff meetings | 0 |
| 2025 49ers record | 2-0 |
San Francisco has a seven-game advantage in the all-time series and a 194-point aggregate scoring advantage.
Recent Individual Records and Milestones
- Trey McBride recorded 126 receptions in 2025, establishing a new single-season Cardinals franchise record.
- McBride’s 126 receptions also set a new single-season NFL record for tight ends, according to NFL’s 2026 player profile.
- McBride became the first tight end to produce consecutive 100-reception seasons.
- McBride recorded 1,239 receiving yards and 11 touchdowns in 2025.
- Christian McCaffrey produced 2,126 scrimmage yards in 2025.
- McCaffrey finished 2025 with 17 total touchdowns.
- George Kittle reached 8,008 career receiving yards through 2025.
- Larry Fitzgerald finished his Cardinals career with 17,492 receiving yards and 1,432 receptions.
- Jerry Rice remains the 49ers’ career leader in receiving yards and receiving touchdowns.
Awards and Honors
Christian McCaffrey
| Award/Honor | Achievement |
| AP Offensive Player of the Year | 2023 |
| Jim Brown Award | 2023 |
| AP First-Team All-Pro | 2023 |
| Pro Bowl | Multiple selections |
| 2025 AP recognition | AP First-Team All-Pro; MVP voting; Offensive Player of Year voting |
McCaffrey won the 2023 AP Offensive Player of the Year award and the Jim Brown Award after producing 1,459 rushing yards, 2,023 scrimmage yards and 21 touchdowns. He was also a unanimous first-team AP All-Pro selection that season.
George Kittle
Kittle has earned multiple Pro Bowl selections and AP All-Pro honors. He was included among San Francisco’s 2023 AP All-Pro selections and was selected to the 2025 Pro Bowl Games.
Trey McBride
McBride was selected to the 2025 Pro Bowl Games and earned AP first-team recognition for his 2025 season. His 126-catch campaign became one of the most productive receiving seasons by a tight end in NFL history.
Kyler Murray
Murray won AP Offensive Rookie of the Year in 2019 after throwing for 3,722 yards and 20 touchdowns while adding 544 rushing yards and four rushing touchdowns. He became the third player in Cardinals franchise history to win the award.
Larry Fitzgerald
Fitzgerald’s Cardinals career included multiple Pro Bowl selections and first-team All-Pro recognition. His 17,492 receiving yards, 1,432 receptions and 121 receiving touchdowns remain major franchise benchmarks.
Performance Trends
San Francisco’s 2025 Matchup Trend
The two 2025 games produced sharply different statistical profiles.
In September, San Francisco gained 355 yards, including 282 net passing yards, but rushed for only 73 yards. Arizona rushed for 106 yards and controlled possession for 34:39. The 49ers nevertheless won because they made three field goals and Eddy Pineiro converted a 35-yard attempt as time expired.
In November, San Francisco was outgained by 207 yards, yet won 41-22. The 49ers produced five touchdowns, committed no turnovers and went 4-for-5 in the red zone. Arizona committed three turnovers and was penalized 17 times for 130 yards.
Christian McCaffrey Against Arizona
McCaffrey’s 2025 matchup production:
| Date | Rushing | Receiving | Total yards from scrimmage | TDs |
| Sept. 21, 2025 | 17-52 | 10-88 | 140 | 0 |
| Nov. 16, 2025 | 13-81 | 5-40 | 121 | 3 |
| 2025 total | 30-133 | 15-128 | 261 | 3 |
Across the two games, McCaffrey averaged 4.43 yards per rushing attempt and generated 261 yards from scrimmage.
Trey McBride Against San Francisco
| Date | Targets | Receptions | Receiving yards | TDs |
| Sept. 21, 2025 | 8 | 5 | 43 | 1 |
| Nov. 16, 2025 | 11 | 10 | 115 | 1 |
| 2025 total | 19 | 15 | 158 | 2 |
McBride’s two-game 2025 line against San Francisco was 15 receptions for 158 yards and two touchdowns.
George Kittle Against Arizona in 2025
Kittle did not play in the September matchup, but in November he caught 6 of 6 targets for 67 yards and two touchdowns. His two scores accounted for 12 of San Francisco’s 41 points.
Turnover and Penalty Trend
| Metric | Sept. 21 | Nov. 16 |
| 49ers turnovers | 1 | 0 |
| Cardinals turnovers | 1 | 3 |
| 49ers penalty yards | 69 | 15 |
| Cardinals penalty yards | 30 | 130 |
| 49ers touchdowns | 1 | 5 |
| Cardinals touchdowns | 1 | 3 |
The November game was the clearest example of efficiency beating volume. Arizona produced more passing yards, more total yards and more possession time, but San Francisco had the cleaner turnover and penalty profile and scored more touchdowns.
Historical Context
The 49ers’ all-time franchise profile is substantially more accomplished than Arizona’s in terms of championships. San Francisco has won five Super Bowls in eight appearances, while the Cardinals have one Super Bowl appearance and no Super Bowl victories.
San Francisco’s historical offensive leaders include Joe Montana, Frank Gore and Jerry Rice. Montana’s 35,124 passing yards, Gore’s 11,073 rushing yards and Rice’s 19,247 receiving yards form the franchise’s principal career statistical benchmarks.
Arizona’s most significant receiving benchmark belongs to Larry Fitzgerald. He finished with 1,432 receptions and 17,492 receiving yards, while his 121 receiving touchdowns remain the Cardinals’ career record.
Trey McBride’s 2025 season changed Arizona’s single-season receiving record book. His 126 receptions surpassed the previous Cardinals single-season mark and placed him among the most productive tight ends in NFL history.
Christian McCaffrey’s 2025 season also fits into a broader NFL historical context. His 2,126 scrimmage yards made him one of the league’s most productive all-purpose offensive players, following his 2023 season in which he accumulated 2,023 scrimmage yards and won AP Offensive Player of the Year.
Head-to-Head Statistics
All-Time Head-to-Head
| Category | 49ers | Cardinals |
| Games | 69 | 69 |
| Wins | 38 | 31 |
| Losses | 31 | 38 |
| Ties | 0 | 0 |
| Winning percentage | .551 | .449 |
| Points scored | 1,628 | 1,434 |
| Playoff games | 0 | 0 |
| Playoff wins | 0 | 0 |
San Francisco leads the all-time matchup 38-31 and has outscored Arizona 1,628-1,434.
Head-to-Head, 2025
| Statistic | 49ers | Cardinals |
| Wins | 2 | 0 |
| Points | 57 | 37 |
| Total yards | 636 | 748 |
| Rushing yards | 168 | 142 |
| Gross passing yards | 484 | 611 |
| Touchdowns | 6 | 4 |
| Turnovers | 1 | 4 |
| First downs | 43 | 40 |
| 2025 series result | 2-0 | 0-2 |
Arizona gained more total yards over the two 2025 meetings, but San Francisco won both games. The 49ers’ combined turnover margin was +3.
2025 Player Head-to-Head
| Player | Team | Sept. 21 | Nov. 16 | 2025 Series Total |
| Christian McCaffrey | SF | 17 rush, 52 yds; 10 rec, 88 yds | 13 rush, 81 yds; 5 rec, 40 yds | 30 rush, 133 yds; 15 rec, 128 yds; 3 TD |
| Trey McBride | ARI | 5 rec, 43 yds, 1 TD | 10 rec, 115 yds, 1 TD | 15 rec, 158 yds, 2 TD |
| George Kittle | SF | Did not play | 6 rec, 67 yds, 2 TD | 6 rec, 67 yds, 2 TD |
| Ricky Pearsall | SF | 8 rec, 117 yds | 1 rec, 0 yds | 9 rec, 117 yds |
| Michael Wilson | ARI | 1 rec, 5 yds | 15 rec, 185 yds | 16 rec, 190 yds |
| Jauan Jennings | SF | Inactive | 4 rec, 54 yds | 4 rec, 54 yds |
The September and November games illustrate how different individual performances can be within the same divisional matchup. Wilson had only one catch for five yards in September before exploding for 15 receptions and 185 yards in November.
Recent Form
The 2025 season is the most recent completed NFL season.
San Francisco 49ers — 2025
| Category | 2025 |
| Regular-season record | 12-5 |
| NFC West finish | 2nd |
| Points scored | 437 |
| Points allowed | 371 |
| Points per game | 25.7 |
| Points allowed per game | 21.8 |
| Playoff result | Divisional Round |
| Wild Card | Won 23-19 vs. Philadelphia |
| Divisional Round | Lost 6-41 vs. Seattle |
San Francisco finished 12-5, won its Wild Card game against Philadelphia, then lost to Seattle in the divisional round.
Arizona Cardinals — 2025
| Category | 2025 |
| Regular-season record | 3-14 |
| NFC West finish | 4th |
| Points scored | 355 |
| Points allowed | 488 |
| Points per game | 20.9 |
| Points allowed per game | 28.7 |
| Playoffs | Did not qualify |
Arizona’s 3-14 record was accompanied by a -133 point differential. The Cardinals averaged 20.9 points per game while allowing 28.7.
Recent 49ers Form
| Date | Opponent | Result |
| Jan. 3, 2026 | Seattle | L 3-13 |
| Dec. 28, 2025 | Chicago | W 42-38 |
| Dec. 22, 2025 | Indianapolis | W 48-27 |
| Dec. 14, 2025 | Tennessee | W 37-24 |
| Nov. 30, 2025 | Cleveland | W 26-8 |
The 49ers entered the 2026 offseason after a 12-5 regular season and a divisional-round playoff loss to Seattle.
Recent Cardinals Form
| Date | Opponent | Result |
| Jan. 4, 2026 | LA Rams | L 20-37 |
| Dec. 28, 2025 | Cincinnati | L 14-37 |
| Dec. 21, 2025 | Atlanta | L 19-26 |
| Dec. 14, 2025 | Houston | L 20-40 |
| Dec. 7, 2025 | LA Rams | L 17-45 |
Arizona finished the 2025 season on a five-game losing streak.
Statistical Highlights
- 38-31: San Francisco’s all-time advantage over Arizona.
- 69: Total meetings between the franchises through 2025.
- 2-0: San Francisco’s 2025 record against Arizona.
- 16-15: 49ers’ September 2025 victory.
- 41-22: 49ers’ November 2025 victory.
- 57-37: San Francisco’s aggregate score in the 2025 series.
- 488: Arizona’s total yards in the November game.
- 281: San Francisco’s total yards in the November game.
- 452: Jacoby Brissett’s passing yards in the November matchup.
- 200: Brock Purdy’s passing yards in the November matchup.
- 3: Purdy’s touchdown passes.
- 3: Christian McCaffrey’s total touchdowns in November.
- 6: George Kittle’s receptions in November.
- 67: Kittle’s receiving yards in November.
- 2: Kittle’s receiving touchdowns.
- 15: Michael Wilson’s receptions in November.
- 185: Wilson’s receiving yards in November.
- 10: Trey McBride’s receptions in November.
- 115: McBride’s receiving yards in November.
- 126: McBride’s 2025 receptions, a Cardinals single-season record.
- 1,239: McBride’s 2025 receiving yards.
- 2,126: McCaffrey’s 2025 scrimmage yards.
- 17: McCaffrey’s 2025 total touchdowns.
- 7,589: McCaffrey’s career rushing yards through 2025.
- 8,008: Kittle’s career receiving yards through 2025.
- 17,492: Larry Fitzgerald’s Cardinals career receiving yards.
- 19,247: Jerry Rice’s 49ers career receiving yards.
- 17: Arizona penalties for 130 yards in the November game.
- 0: San Francisco turnovers in the November game.
- 3: Arizona turnovers in the November game.
- 80%: San Francisco red-zone efficiency in November.
- 60%: Arizona red-zone efficiency in November.
Frequently Asked Questions
Who won the 49ers vs Arizona Cardinals games in 2025?
The San Francisco 49ers won both meetings. They beat Arizona 16-15 on September 21, 2025, and 41-22 on November 16, 2025.
What is the all-time 49ers vs Cardinals record?
The 49ers lead the all-time series 38-31, with no ties across 69 meetings.
Who had the most receiving yards in the 49ers vs Cardinals matchup?
Michael Wilson had the largest receiving performance in the two 2025 meetings, catching 15 passes for 185 yards on November 16.
How many yards did Christian McCaffrey have against the Cardinals in 2025?
McCaffrey accumulated 261 yards from scrimmage in the two 2025 games: 133 rushing yards and 128 receiving yards. He scored three touchdowns, all in the November meeting.
How many touchdowns did George Kittle score against Arizona in 2025?
Kittle scored two receiving touchdowns in the November 16 game. He did not play in the September meeting.
How many receiving yards did Trey McBride have against the 49ers in 2025?
McBride recorded 158 receiving yards across the two games, with 43 yards and a touchdown in September followed by 115 yards and a touchdown in November.
Who was the 49ers quarterback in the September 2025 game?
Mac Jones started the September 21 matchup. He completed 27 of 41 passes for 284 yards, one touchdown and one interception.
Who was the 49ers quarterback in the November 2025 game?
Brock Purdy started the November 16 matchup. He completed 19 of 26 passes for 200 yards, three touchdowns and no interceptions, producing a 133.5 passer rating.
Who was Arizona’s quarterback in the November 2025 game?
Jacoby Brissett started for Arizona and completed 47 of 57 passes for 452 yards, two touchdowns and two interceptions.
Which team had more total yards in the November 2025 game?
Arizona had more total yards, 488 to 281, but San Francisco won 41-22. The 49ers’ advantage came from turnovers, touchdowns, red-zone efficiency and penalties.
How many turnovers did Arizona have against San Francisco in November 2025?
Arizona had three turnovers: two interceptions and one lost fumble. San Francisco had none.
Did the 49ers sweep the Cardinals in 2025?
Yes. San Francisco won both regular-season meetings and finished the 2025 series 2-0.
What was Trey McBride’s 2025 season?
McBride caught 126 passes for 1,239 yards and 11 touchdowns in 17 games. His 126 receptions established a Cardinals single-season record and earned him Pro Bowl and AP first-team recognition.
What was Christian McCaffrey’s 2025 season?
McCaffrey rushed for 1,202 yards and 10 touchdowns and added 924 receiving yards and seven receiving touchdowns, producing 2,126 scrimmage yards and 17 total touchdowns.
Have the 49ers and Cardinals ever met in the playoffs?
No. The all-time head-to-head database lists zero playoff meetings between San Francisco and Arizona.
Sources and References
- NFL official gamebooks: The September 21, 2025 and November 16, 2025 NFL gamebooks provide the official scoring summaries, individual player statistics, team statistics, defensive statistics, turnovers, penalties and possession data.
- Pro Football Reference: Used for the all-time 49ers-Cardinals head-to-head record, franchise leaders, 2025 team statistics, player season statistics and historical game results.
- NFL.com player statistics: Used to verify career and season statistics for Christian McCaffrey, George Kittle, Trey McBride, Kyler Murray and Larry Fitzgerald.
- NFL Football Operations / NFL Honors: Used to verify Pro Bowl selections and major award results, including McCaffrey’s 2023 AP Offensive Player of the Year award and Jim Brown Award.
- NFL.com 2026 player rankings: Used to verify McBride’s 2025 record-setting receiving season and his All-Pro and Pro Bowl recognition.
- StatMuse and historical matchup databases: Used as secondary verification for the recent 49ers-Cardinals series trend.
All matchup statistics in this article are based on verified NFL gamebooks and established statistical databases. Where a requested historical figure could not be independently verified from the available sources, it has not been presented as a confirmed statistic.
